Poison Creek Cutoff is a well-maintained gravel road that goes from Mud Flat Road, aka the Owyhee Back Country Scenic Byway, to near the little town of Oreana. For much of its length, the road parallels the foothills of the Owyhee Mountains, with several side roads going over to and, presumably, into the foothills. Those traveling south on Highway 78 and desiring to get onto Mud Flat Road can save quite a few miles by taking the Cutoff.
As it follows the foothills of the Owyhee Mountains, Poison Creek Cutoff winds into and through interesting and scenic small draws and canyons. The largest draw is toward the south end, and the climb out is steep and winding with limited visibility, making it the hardest part of the road. Because it is a well maintained gravel road it can be driven in most any vehicle but care does need to be taken for other vehicles. Since the area is open range, there could be cattle on or near the road.
Dispersed camping is allowed along Poison Creek Cutoff, but there are no obvious campsites.